HBP Hippocamp CA1: Collaborative and Integrative Modeling of Hippocampal Area CA1

31st March-1st April 2015, London, United Kingdom

UCL School of Pharmacy

Hippocampus CA1, a brain region fundamental for learning and memory, is one of the most intensely studied brain areas world-wide. This means an enormous quantity of data, but also heterogeneity in terms of sources, methods, quality, etc. Integrating the available anatomical and physiological data in a unified model of hippocampus CA1, and validating it broadly against known phenomena, is a challenging but feasible prospective given the HBP platforms roadmap.

In short, the aims of the workshop are two-fold. First, to engage the larger community of experimentalists and modelers working on hippocampus, and highlight existing modeling efforts and strategic datasets for modeling Hippocampal CA1. Second, to define and bootstrap an inclusive community-driven model and data-integration process to achieve open pre-competitive reference models of hippocampus CA1, which are well documented, validated, and released at regular intervals (supported in part by IT infrastructure funded by HBP). Involvement from the community interested in characterization and modeling of hippocampus CA1 is highly encouraged.

The first day will be scientific presentations on modeling approaches, key datasets, problems and solutions, and some information on HBP activities relevant to the meeting. Instead of having regular research talks discussing the speaker's current research in detail, we aim to have shorter talks which either highlight important sources of experimental data (also discussing limitations etc.) or describe specific problems or solutions that are relevant to building a data-driven CA1 model. There will be ample time for discussion following talks. The second day will be highly interactive, and will have the objective of bootstraping a community process for planning, coordinating, reviewing, documenting, and validating regular releases of open integrative pre-competitive reference models of hippocampus CA1. For this format to be effective, the meeting size has been intentially limited. There will be a poster session during lunches.

Organization

The meeting was held at the UCL School of Pharmacy, located at 29-39 Brunswick Square in London, United Kingdom. The meeting was organised by Jo Falck, Szabolcs Káli, Sigrun Lange, Audrey Mercer, Eilif Muller, Armando Romani and Alex Thomson.

Participants

  • Christine Aicardi21
  • Giorgio Ascoli19
  • Marlene Bartos2,20
  • Mark Cembrowski10
  • Jonathan Cornford12
  • Javier Defelipe15
  • Jose R. Donoso8
  • Pissadaki Eleftheria Kyriaki11
  • Kathleen Elsig3,22
  • Jo Falck12
  • Padraig Gleeson5
  • Bruce Graham7
  • Attila Gulyas13
  • Jose Guzman16
  • Linda Katona6
  • Thomas Klausberger18
  • Szabolcs Káli13
  • Sigrun Lange12
  • Tara Mahfoud21
  • Audrey Mercer12
  • Eilif Muller1
  • Srikanth Ramaswamy1
  • Christian Roessert1
  • Armando Romani1
  • Ludovico Silvestri17
  • Nathan Skene9
  • Frances Skinner14
  • Martin Telefont1
  • Alex Thomson12
  • Tim Viney4


Meeting Program

Tue. 31st March

09:00 Welcome
09:00Eilif Muller Opening remarks [PPTX]
09:20 Cellular Level (chair: Audrey Mercer)
09:20Attila Gulyas Anatomical and physiological constraints and parameters for modelling hippocampal neurons in different network states
09:40Audrey Mercer Hippocampal CA1 neurones: morphological features and synaptic interactions
10:00Frances Skinner Hippocampal Interneurons: Model Development Strategies [PDF]
10:30 Coffee
11:00 Cellular Level
11:00Szabolcs Káli Constructing detailed biophysical models of hippocampal pyramidal cells [PDF]
11:20Christian Roessert Multi-objective optimisation of CA1 neuron models - first results and challenges
11:40 Discussion - Community Roadmap - Neurons: State-of-the-art, minimal parameterization and validation datasets
12:30 Lunch and poster session
12:30Pissadaki Eleftheria Kyriaki Poster - From time to phase: temporal delay drives phase precession in the hippocampus
14:00 Microcircuit level (chair: Szabolcs Kali)
14:00Marlene Bartos Distance-dependent inhibition supports focal gamma oscillations in the hippocampus
14:30Mark Cembrowski Subcellular organization of cell type specific inhibitory inputs to CA1 pyramidal neuron dendrites
14:50Jose Guzman Synaptic foundations of pattern completion based on intracellular data [PDF]
15:10Bruce Graham Modelling inhibitory control of encoding and retrieval in CA1 pyramidal cells [PDF]
15:40 Coffee
16:10-18:40 Microcircuit level
16:10Thomas Klausberger Firing patterns of identified hippocampal neurons in vivo
16:40Nathan Skene Synaptic diversity: implications and opportunities for modelling
17:00Srikanth Ramaswamy The neocortical in silico synaptome: parameterization, validation, dissemination
17:20Armando Romani Data-driven hippocampus CA1 modeling in HBP-SP6
17:40 Discussion - Community Roadmap - Synapses and Microcircuits: State-of-the-art, minimal parameterization and validation datatsets
 

Wed. 1st April

09:00 Large-scale datasets (chair: Eilif Muller)
09:00Giorgio Ascoli Hippocampome.Org -- A knowledge base of neuron types for real-scale hippocampal simulations
09:30Martin Telefont Data-integration in the HBP
09:50Ludovico Silvestri Whole Hippocampus high resolution optical imaging [PDF]
10:10Javier Defelipe Exploring the synaptome: promising new technologies
10:40 Coffee
11:10 Large-scale datasets
11:10Padraig Gleeson Hippocampal models in the Open Source Brain Repository
11:30 Discussion - Community Roadmap - Comprehensive: State-of-the-art, minimal parameterization and validation datatsets
12:30 Lunch and poster session
14:00-17:00 Community convergence (chair: Eilif Muller)
14:00Padraig Gleeson Position statement [PPT]
14:05 Discussion of model constraints (data, validations)
16:00 Discussion - next steps
 

Creative Commons License
Unless mentioned otherwise, all the downloadable talks are licenced under a Creative Commons Attribution-Noncommercial-No Derivative Works License.

Support

The meeting organizers gratefully acknowledge support from the European Union through the Human Brain Project from the European Union Seventh Framework Program (FP7/2007-2013) under grant agreement no. 604102 (HBP), and support from the Swiss ETH Domain for the Blue Brain Project (BBP).