HBP Hippocamp CA1: Collaborative and Integrative Modeling of Hippocampal Area CA1
31st March-1st April 2015, London, United Kingdom
Hippocampus CA1, a brain region fundamental for learning and memory, is one of the most intensely studied brain areas world-wide. This means an enormous quantity of data, but also heterogeneity in terms of sources, methods, quality, etc. Integrating the available anatomical and physiological data in a unified model of hippocampus CA1, and validating it broadly against known phenomena, is a challenging but feasible prospective given the HBP platforms roadmap.
In short, the aims of the workshop are two-fold. First, to engage the larger community of experimentalists and modelers working on hippocampus, and highlight existing modeling efforts and strategic datasets for modeling Hippocampal CA1. Second, to define and bootstrap an inclusive community-driven model and data-integration process to achieve open pre-competitive reference models of hippocampus CA1, which are well documented, validated, and released at regular intervals (supported in part by IT infrastructure funded by HBP). Involvement from the community interested in characterization and modeling of hippocampus CA1 is highly encouraged.
The first day will be scientific presentations on modeling approaches, key datasets, problems and solutions, and some information on HBP activities relevant to the meeting. Instead of having regular research talks discussing the speaker's current research in detail, we aim to have shorter talks which either highlight important sources of experimental data (also discussing limitations etc.) or describe specific problems or solutions that are relevant to building a data-driven CA1 model. There will be ample time for discussion following talks. The second day will be highly interactive, and will have the objective of bootstraping a community process for planning, coordinating, reviewing, documenting, and validating regular releases of open integrative pre-competitive reference models of hippocampus CA1. For this format to be effective, the meeting size has been intentially limited. There will be a poster session during lunches.
Organization
The meeting was held at the UCL School of Pharmacy, located at 29-39 Brunswick Square in London, United Kingdom. The meeting was organised by Jo Falck, Szabolcs Káli, Sigrun Lange, Audrey Mercer, Eilif Muller, Armando Romani and Alex Thomson.
Participants
- Christine Aicardi20
- Giorgio Ascoli17
- Marlene Bartos18,19
- Mark Cembrowski10
- Jonathan Cornford2
- Javier Defelipe13
- Jose R. Donoso8
- Pissadaki Eleftheria Kyriaki11
- Kathleen Elsig21,22
- Jo Falck2
- Padraig Gleeson5
- Bruce Graham7
- Attila Gulyas3
- Jose Guzman14
- Linda Katona6
- Thomas Klausberger16
- Szabolcs Káli3
- Sigrun Lange2
- Tara Mahfoud20
- Audrey Mercer2
- Eilif Muller1
- Srikanth Ramaswamy1
- Christian Roessert1
- Armando Romani1
- Ludovico Silvestri15
- Nathan Skene9
- Frances Skinner12
- Martin Telefont1
- Alex Thomson2
- Tim Viney4
- 1Blue Brain Project, EPFL, Switzerland
- 2University College London, London, United Kingdom
- 3Institute for Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary
- 4MRC Anatomical Neuropharmacology Unit, Department of Pharmacology, Oxford University, Oxford, UK
- 5UCL, London, United Kingdom
- 6MRC ANU, University of Oxford, Oxford, United Kingdom
- 7University of Stirling, Stirling, U.K.
- 8Institute for Theoretical Biology / Bernstein center for Computational Neuroscience, Berlin, Germany
- 9Seth Grant lab, University of Edinburgh, Edinburgh, United Kingdom
- 10Howard Hughes Medical Institute, Janelia Research Campus, Ashburn, VA, United States
- 11Dept of Computer Science, University of Sheffield and MRC Anatomical Neuropharmacology Unit, Oxford, UK, Oxford, UK
- 12University of Toronto, Toronto, Canada
- 13Cajal Institute, Madrid, Spain
- 14IST, Klosterneuburg, Austria
- 15LENS, Florence, Italy
- 16Medical University of Vienna, Vienna, Austria
- 17Krasnow Institute for Advanced Study, Fairfax, USA
- 18Bernstein Center Freiburg, Freiburg, Germanz
- 19University of Freiburg, Freiburg, Germany
- 20King's College London, London, UK
- 21EPFL, Switzerland
- 22Human Brain Project, Geneva, Switzerland
Meeting Program
Tue. 31st March | ||
| 09:00 | Welcome | |
| 09:00 | Eilif Muller | Opening remarks [PPTX] |
| 09:20 | Cellular Level (chair: Audrey Mercer) | |
| 09:20 | Attila Gulyas | Anatomical and physiological constraints and parameters for modelling hippocampal neurons in different network states |
| 09:40 | Audrey Mercer | Hippocampal CA1 neurones: morphological features and synaptic interactions |
| 10:00 | Frances Skinner | Hippocampal Interneurons: Model Development Strategies [PDF] |
| 10:30 | Coffee | |
| 11:00 | Cellular Level | |
| 11:00 | Szabolcs Káli | Constructing detailed biophysical models of hippocampal pyramidal cells [PDF] |
| 11:20 | Christian Roessert | Multi-objective optimisation of CA1 neuron models - first results and challenges |
| 11:40 | Discussion - Community Roadmap - Neurons: State-of-the-art, minimal parameterization and validation datasets | |
| 12:30 | Lunch and poster session | |
| 12:30 | Pissadaki Eleftheria Kyriaki | Poster - From time to phase: temporal delay drives phase precession in the hippocampus |
| 14:00 | Microcircuit level (chair: Szabolcs Kali) | |
| 14:00 | Marlene Bartos | Distance-dependent inhibition supports focal gamma oscillations in the hippocampus |
| 14:30 | Mark Cembrowski | Subcellular organization of cell type specific inhibitory inputs to CA1 pyramidal neuron dendrites |
| 14:50 | Jose Guzman | Synaptic foundations of pattern completion based on intracellular data [PDF] |
| 15:10 | Bruce Graham | Modelling inhibitory control of encoding and retrieval in CA1 pyramidal cells [PDF] |
| 15:40 | Coffee | |
| 16:10-18:40 | Microcircuit level | |
| 16:10 | Thomas Klausberger | Firing patterns of identified hippocampal neurons in vivo |
| 16:40 | Nathan Skene | Synaptic diversity: implications and opportunities for modelling |
| 17:00 | Srikanth Ramaswamy | The neocortical in silico synaptome: parameterization, validation, dissemination |
| 17:20 | Armando Romani | Data-driven hippocampus CA1 modeling in HBP-SP6 |
| 17:40 | Discussion - Community Roadmap - Synapses and Microcircuits: State-of-the-art, minimal parameterization and validation datatsets | |
Wed. 1st April | ||
| 09:00 | Large-scale datasets (chair: Eilif Muller) | |
| 09:00 | Giorgio Ascoli | Hippocampome.Org -- A knowledge base of neuron types for real-scale hippocampal simulations |
| 09:30 | Martin Telefont | Data-integration in the HBP |
| 09:50 | Ludovico Silvestri | Whole Hippocampus high resolution optical imaging [PDF] |
| 10:10 | Javier Defelipe | Exploring the synaptome: promising new technologies |
| 10:40 | Coffee | |
| 11:10 | Large-scale datasets | |
| 11:10 | Padraig Gleeson | Hippocampal models in the Open Source Brain Repository |
| 11:30 | Discussion - Community Roadmap - Comprehensive: State-of-the-art, minimal parameterization and validation datatsets | |
| 12:30 | Lunch and poster session | |
| 14:00-17:00 | Community convergence (chair: Eilif Muller) | |
| 14:00 | Padraig Gleeson | Position statement [PPT] |
| 14:05 | Discussion of model constraints (data, validations) | |
| 16:00 | Discussion - next steps | |
Unless mentioned otherwise, all the downloadable talks are licenced under a Creative Commons Attribution-Noncommercial-No Derivative Works License.
Support
The meeting organizers gratefully acknowledge support from the European Union through the Human Brain Project from the European Union Seventh Framework Program (FP7/2007-2013) under grant agreement no. 604102 (HBP), and support from the Swiss ETH Domain for the Blue Brain Project (BBP).